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Aims: Native practices in poor regions of Africa takes local herbs with orthodox medicine fortreatment of diabetes. This study investigates the roles of Thaumatococcus daniellii methanolleaves extract in combination with Glibenclamide.Study Design: 35 male Wistar rats averagely weighing 150 g treated for 15 days, were randomlyselected into seven groups; A (Control), B (Streptozotocin-induced diabetic rats), C (Diabetic ratsadministered 100 mg/kg/day body weight of extract), D (Diabetic rats administered therapeuticdose of Glibenclamide), E (Diabetic rats treated with therapeutic dose of Glibenclamide and 100mg/kg/day bodyweight of extract), F (Extract only) and G (Glibenclamide only).Methodology: Haematological, lipid profile and antioxidant parameters were evaluated using international standardized methods.Results: Results showed that Streptozotocin-induced diabetic rats (group B) elicits significant(P=.05) increases in haematological parameters such as fasting blood glucose level, white bloodcell counts, lymphocytes and platelets with corresponding decreases in red blood cell counts andserum protein while it also exhibits significant (P=.05) increases in serum total cholesterol,triglycerides and a significant (P=.05) decrease in high density lipoprotein (HDL) Cholesterol withcorresponding decreases in liver reduced glutathione level, superoxide dismutase and catalaseactivities as well as elevated levels of malondialdehyde. However, extract and Glibenclamideshowed anti-diabetic effects as levels and activities of these markers were restored nearly tocontrols in groups C, D and E with significant effects exhibited by group C and in the order C>D=E.Conclusion: Results are suggestive of the anti-diabetic and modulatory effects of the extract onGlibenclamide activity and its use could be encouraged

british journal of pharmaceutical research

Thaumatococcus daniellii Extract Modulates Glibenclamide Activity and Ameliorates Heamatological Disorders, Oxidative Stress and Dyslipidemia Associated with Diabetes Mellitus in Rats