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23 The objective of the study was to comparatively verify the effects of aqueous extracts of three 24 plants on some biochemical parameters following ethanol administration with a view to 25 ascertaining the role of the extracts in ameliorating ethanol toxicity. 26 A total of forty rats were divided into eight groups (n=5). Group A were control rats; Group B 27 were administered with absolute ethanol; Group C were ethanol administered rats treated with 28 Xylopia aethiopica; Groups D were ethanol administered rats treated with Fiscus mucuso, Group 29 E were ethanol administered rats treated with Anthocleista vogelli; Group F were normal rats 30 administered orally with Xylopia aethiopica; Group G were normal rats administered orally with 31 Fiscus mucuso; Group H were normal rats administered orally with Anthocleista vogelli. At the 32 end of the experimental period, the animals were sacrificed and serum was obtained for total 33 protein, uric acid, creatinin, urea, Aspartate aminotrasferase (AST) and Alanine aminotransferase 34 (ALT) analysis using respective research kits. 35 The result showed that Xylopia aethiopica had protective effect on the kidney as compared with 36 Fiscus mucuso and Anthocleista vogelli treated rats. Also, The AST and ALT was lowered with 37 the start of Xylopia aethiopia treatment. The total protein, creatinin and urea were slightly 38 (p>0.05) affected with ethanol, an effect which was normalized with the start of extract 39 treatment. 40 It can be concluded that Xylopia aethiopica had a better reno-protective and hepatoprotective 41 effect than Anthocleista vogelli and Fiscus mucuso extract as evidenced in its role in normalizing 42 the negative influence of ethanol toxicity. 43

Effect of Xylopia aethiopica, Fiscus mucuso and Anthocleista vogelli Extracts on Some Biochemical Parameters Following Ethanol-induced Toxicity