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Iron deficiency anaemia includes the highest incidence of nutritional deficiency diseases in the world. Red cell indices on full blood counts is regularly used to diagnose early anaemia. Currently strategies medicines of iron deficiency anaemia are belonged to preventif medicine as well as fortification of food and iron supplementation directly to the body. Recent studies show the effectiveness of treatment of iron deficiency anaemia in rats with squid ink. This study aim is to analyse the iron content of squid ink (Sepioteuthis lessoniana) and squid ink effects on haematological profile of male Wistar rat Rattus norvegicus. The measured iron content of squid ink (Sepioteuthis lessoniana) is 2,14 ± 0,46 mg/g. Rats were used in this study, are induced NaNO2 (50 mg/kgbw (1 ml dosing volume)) at first, then divided into 4 groups experiment for 14 days experimental. The 1 st group is negative control (without any treatment), 2 nd group is positive control (with Sangobion), 3 group is given a low dosage of squid ink (10 mg/kgbw/day) and the last 4 th group is given a high dosage of squid ink (100 mg/kgbw/day). Based on the result, there was an effect of given squid ink to the haemoglobin, hematocrit, mean corpuscular volume, mean corpuscular haemoglobin concentration, mean haemoglobin content, red blood cell distribution width and red blood cell count of rats that showed by increasing numbers to the end of the Original Research Article Pringgenies et al.; ARRB, 35(1): 39-49, 2020; Article no.ARRB.55320 40 experiment compared to the negative control (1 st group). The most significant effect is in haemoglobin, especially Hb of rats which appeared on the low dosage of squid ink group and positive control group to the negatif group (p<0,05).

Effect of Squid (Sepiotheutis lessoniana) Ink on Hematological Profile of Rats Rattus norvegicus