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Aims: This study aims to determine the regulation of β3 integrin protein in the period of embryo implantation after being induced by oil atsiri of purple nutsedge tubers. Study Design:  The study employed a completely randomised design using four concentration levels repeated six times. Place and Duration of Study: Organic Chemistry Laboratory and Zoology Laboratory of Faculty of Mathematics and Natural Sciences University of Lampung, between June 2015 and April 2016. Methodology: This study used mouse as experimental animals with 24 female mouse, then mated with male mouse with a ratio (1 female: 1 male). After the vaginal plug was found in female mouse, then the essential oil of purple nutsedge tubers was induced orally (force-fed) according to the treatment dose. Each 6 female mice were grouped as a control group, and 3 treatment groups, consisting of controls (C) = 0.4 ml aquabides, treatment 1 (T1) = 4.5 mg/40g body weight, treatment 2 (T2) = 45 mg/40g body weight, and treatment 3 (T3) = 135 mg/40g body weight. After the one way Anova test, Ho is rejected, meaning there are significant differences and the analysis is continued with multiple comparison tests, in this case the Least Significant Difference (LSD) test is used. Results: The results shown that the induction of essential oils of purple nutsedge tubers can reduce the level of β3 integrin protein in uterus mouse significantly. Conclusion: It is suggested essential oil of purple nutsedge tubers has potential decrease and can reduce the level of β3 integrin protein in uterus mouse during the period of embryo implantation.

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Regulation of Integrin β3 Protein Secretion on Implantation Embryo of Mouse (Mus musculus L.) Induced by Oil Atsiri of Purple Nutsedge Tubers (Cyperus rotundus L.)