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Background: The association between diabetes mellitus and inflammation is established but the use of non-steroidal anti-inflammatory drugs is not without some health risk. Aim: The study was aimed at comparing the levels of some inflammatory biomarkers in diabetic rats treated with aqueous leaf extract of Terminalia catappa, non steroidal anti-inflammatory drugs (NSAIDs) and exogenous insulin. Materials and Methods: Thirty six (36) Wistar rats were assigned to 6 groups of 6 animals each. Group 1 and 2 served as normal and diabetic controls and received orally 5ml/kg body weight of distilled water. Group 3 was diabetic treated orally with 130mg/kg body weight of aqueous leaf extract of Terminalia catappa. And groups 4, 5 and 6 were administered orally with aspirin (30mg/kg), meloxicam (2mg/kg) and 0.75U/kg body weight of insulin subcutaneously. Diabetes was induced with intraperitoneal injection of 150mg/kg body weight of alloxan solution and diabetes confirmed after 72 hours with blood glucose levels ≥200mg/dl. The experiment lasted for 14 days Original Research Article Ben et al.; AJRB, 4(1): 1-10, 2019; Article no.AJRB.47442 2 and blood was collected by cardiac puncture for serum analysis of C-reactive protein, Interleukin-6 and Fibrinogen by ELISA method. Results: The results showed significant (P<0.05) increase in serum levels of C-reactive protein, Interleukin-6 and blood fibrinogen in diabetic group compared to control. These inflammatory biomarker were significantly (P<0.05) reduced by the extract, aspirin, meloxicam and insulin. Conclusion: The reduced levels of C-reactive protein, Interleukin-6 and fibrinogen by aqueous leaf extract of Terminalia catappa was significant compared to aspirin and meloxicam. This may present the extract as a potent anti-inflammatory agent and could complement the function of insulin in diabetes treatment.

asian journal of research in biochemistry

Comparative Effect of Aspirin, Meloxicam and Terminalia catappa Leaf Extract on Serum Levels of Some Inflammatory Markers in Alloxan Induced Diabetic Rats