Evaluation of Serum Levels of Endothelial Adhesion Molecules: Leukocyte Adhesion Molecule-1 (LAM-1), CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) in Fibrotic Patients

Leukocyte adhesion molecule-1 (LAM-1), CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) are adhesion molecules and constitute important steps in the liver inflammation due to chronic hepatitis C. We measured soluble intercellular adhesion molecule (LAM-1), (LFA-1) and (Mac-1) as well as cholesterol and triglyceride concentrations in the serum of 120 patients with fibrosis. A study was carried out to analyze levels of LAM-1, LFA-1 and Mac-1in fibrotic patients, and find whether increasing with cholesterol and triglycerides. 120 serum samples from fibrotic patients were Original Research Article Mosa et al.; AJRB, 2(1): 1-9, 2018; Article no.AJRB.40834 2 classified according to levels of Cholesterol and Triglycerides concentration into four groups. Positive LAM-1 samples were found in 90% of patients in first group, 83% in the second group, 73% in the third group and 46% in the fourth group. These levels were significantly higher than their levels in control group (p<0.0001) indicating extremely significant. Level of LAM-1in group (1) was extremely significant compared to group (4) (356 ± 70.5 vs. 209± 5 p < 0.0001 ES). High LFA-1level was found in 76% in first group, 73% in the second group, 70% in the third group, and 40% in the fourth group. The levels of MAC-1 in first group were significantly greater than their levels in control group (p<0.0001), and +ve MAC-1 samples were found in 66% in first group, 53% in the second group, 46% in third group, and 36% in fourth group. AST and ALT were significantly higher in first group, compared to healthy group (95.68 ± 33.32 vs. 31.77 ± 8.11, p < 0.001) for AST and (78.6 ± 29.86 vs. 28.55 ± 7.15 p < 0.001) for ALT indicating very significant relationship, while no significant was detected between the fourth group and healthy individuals (33.56±8.16 vs. 28.55 ± 7.15 p = 0.05 NS). Our study showed a significant increase in levels of LAM-1 and LFA-1 rather than MAC-1 in fibrosis compared to healthy individuals. The results showed the ability to circulate LAM-1 and LFA-1 to predict fibrosis disease and evaluated the relationship between circulating adhesion molecules and fibrotic patients.