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The effect of a daily consumption of Instant noodle seasoning containing the Monosodium glutamate (MSG) on rat was evaluated, The parameters investigated include; Alkaline aminotransferase (ALT), Aspartate aminotransferase (AST). Hemoglobin (Hb), packed cell volume (PCV) white blood cell (WBC), protein, platelets, lymphocytes and Serum electrolytes; sodium (Na + ), potassium (K + ) chloride (Cl), bicarbonate (HCO3 ). Sperm count was also investigated. The results revealed the following, the mean PCV was 29 and 25.13on week 1 and week 4, with an average control of 30.69, mean Hb was 10 in week 1 and 6.57 in week 4, RBC had an average control of 5.28 while week 1 had a mean of 4.77 and week 4 3.67, there was a significant difference (P<0.05) for PCV and Hb. The mean WBC and Lymphocyte were 6 and 61 in the first week, and 5.8 and 60.17 on the fourth week, with an average control of 5.28 for WBC and 77.53 Original Research Article Obemeata and Blessing; AFSJ, 7(2): 1-8, 2019; Article no.AFSJ.40694 2 for lymphocytes. Platelet had a mean of 251 on the first week and a mean of 532 on the fourth week with a significant difference across the group in WBC and platelets (P<0.05). The mean serum Na, K and Cl reduced from 140.67, 4.13 and 100.67 in week 1 to 116, 2.5 and 98 in week 4 with a significant difference (P<0.05) across the group when compared to the average control for Na and K. HCO3 had a mean of 23.67 in week 1 and a mean of 22.67 in week 4 in the treated group. AST had a mean of 24 in week 1 which increased to 41.67 in week 4 while ALT increased from a mean of 4.00 in week 1 and 28 in week 4 with a significant difference (P<0.05) across the group. The mean serum protein was 51.93 in week 1 and a 74.29 in week 4. The mean sperm count was 800, 299.67, 450.67 and 501 for week 1, 2, 3 and 4 respectively. The results indicates that daily consumption of Instant noodle seasoning may cause liver damage, and kidney dysfunction and has been discovered to have negative effects on blood and sperm cells.

Reproductive & Biomarker Response to a Daily Dose of Instant Noodle Seasoning in Male Albino Rats (Rattus norvegicus)