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Recently, the level set has become a popular method in many research fields. The main reason is that it can be modified into many variants. One such case is our proposed method. We describe a contrast-enhancement method to segment the hippocampal region from the background. However, the hippocampus region has quite similar intensities to the neighboring pixel intensities. In addition, to handle the inhomogeneous intensities of the hippocampus, we used a bias correction before hippocampal segmentation. Thus, we developed a contrast-enhanced bias-corrected distance-regularized level set (CBDLS) to segment the hippocampus in magnetic resonance imaging (MRI). It shows better performance than the distance-regularized level set evolution (DLS) and bias-corrected distance-regularized level set (BDLS) methods in 33 MRI images of one normal patient. Segmentation after contrast enhancement and bias correction can be done more accurately than segmentation while not using a bias-correction method and without contrast enhancement.

Contrast-enhanced Bias-corrected Distance-regularized Level Set Method Applied to Hippocampus Segmentation