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IgY         .    3-zone 4-zone SMB    IgY   .       SMB   . Aspen simulator    IgY    3-zone 4-zone SMB      . IgY       ,  ( $m_2$ , $m_3$ =0.1, 0.1, 1.1) 3-zone SMB   . IgY   4-zone SMB ( $m_2$ , $m_3$ =0.06 0.06, 0.5)   IgY   . recycle  3-zone SMB    extract      . 【IgY (Immunoglobulin Yolk) is a specific antibody in egg yolk, and it protects human body from virus and antigen. There are a lot of egg yolk components such as lipoprotein and protein. To separate IgY, HPLC (High Performance Liquid Chromatography) and precipitation were used in a batch mode and SMB (Simulated Moving Bed) was adopted for continuous purification of yolk proteins. IgY and other proteins in yolk were separated by using three-zone and four-zone SMB chromatography. Before performing SMB experiments, batch chromatography simulation parameters and adsorption isotherms were obtained. The parameters of batch chromatography were used to simulate SMB using Aspen chromatography. To compare three-zone and four-zone SMB chromatography, simulations in $m_2-m_3$ plane on the triangle theory were carried out. In terms of concentration and purity of both IgY and other lipoproteins, 3-zone SMB process is considered as ideal at the vertex of triangle ( $m_2$ , $m_3$ =0.1, 0.1, 1.1). 4-zone SMB yields the highest IgY purity at the coordinate ( $m_2$ , $m_3$ =0.06 0.06, 0.5), which is the pure raffinate region. In 3-zone SMB without recycle, other lipoproteins in extract are largely affected in purity by small shift from the vertex of triangle ( $m_2$ , $m_3$ =0.1, 0.1, 1.1).】

Comparative Simulation of 3-zone SMB (Simulated Moving Bed) and 4-zone SMB for IgY (Immunoglobulin Yolk) Purification