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Non-alcoholic fatty liver disease (NAFLD) is emerging as an important cause of chronic liver disease, characterized by significant lipid deposition in hepatocytes. The prevalence of NAFLD in India is around 35% with higher prevalence in urban areas. In view of high prevalence and absence of any approved therapies for NAFLD, this clinical trial was attempted to evaluate the efficacy and safety of Dawa-ul-Kurkum in Non-alcoholic fatty liver disease (Su-e-Mizaj Kabid Barid). A randomized single blind placebo controlled trial was conducted in 44 cases of non-alcoholic fatty liver disease, diagnosed by ultra-sonogram of abdomen. They were randomly assigned in to two equal groups, after obtaining voluntary informed consent, of them 40 had completed the protocol and the rest 4 were lost to follow-up. Test group was administered Dawa-ul-Kurkum 5 gm once daily for 60 days, while the control group received Suji Halwa in similar dose and for same duration. All the cases were followed up every 15 th day. The results were statistically analyzed at the completion of trail. The test formulation showed statistically significant reduction in subjective and objective parameters (p<0.05), both in intergroup and intra group comparison, while placebo controlled group showed statistically insignificant effect (p>0.05). This study exhibits that the test drug; Dawa-ul-Kurkum has potential to reduce the symptoms and grading of NAFLD. There was no any adverse effect observed in this study. Hence it can be concluded that the test drug Dawa-ul-Kurkum is effective and safe in the management of NAFLD.

journal of biological and scientific opinion

EVALUATION OF THE EFFICACY OF DAWA-UL-KURKUM IN SU-E-MIZAJ KABID BARID (NON-ALCOHOLIC FATTY LIVER DISEASE): A RANDOMIZED SINGLE BLIND PLACEBO CONTROLLED STUDY