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Strychnine is a natural alkaloid obtained from the dried seeds of Strychnos nux vomica. It occurs as colourless, odourless, rhombic prisms, having an intensely bitter taste. The seeds contains about 1.1 -1.4% strychnine. It is a spinal poison & the chief chemical constituent that accounts for the toxic manifestations and is 10 to 20 times more poisonous than brucine. Tonic – clonic convulsions are the characteristic clinical manifestation seen in strychnine poisoning. Kupilu is one among the upavishas that comes under the category of sthavara visha. References regarding the drug kupilu are mentioned in the classical texts according to the time period. There is no reference of kupilu in vedakala and samhitakala and was not reported in the ‘BrihatTrayee’ texts of Ayurveda. In samgrahakala, the reference of visamusti as one of the ingredient of the formulation Agnitundirasa can be seen inSharngadhara samhita. Toxicity is the degree at which a substance can damage a tissue or organ. It can be acute, sub-acute and chronic. In the present study 5 groups were taken; group1 – control, group2 – ashodhita kupilu(1/5 LD50), group3ashodhita kupilu (1/10 LD50), group4strychnine(1/5 LD50) and group5strychnine (1/10 LD50). Significant results were observed in the 1/5 LD50 strychnine received group when compared to ashodhita kupilu (1/5 LD50) treated group.

A COMPARATIVE TOXICOLOGICAL EVALUATION OF STRYCHNINE AND ASHODHITA KUPILU IN WISTAR ALBINO RATS