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Alcohol withdrawal is characterized by a cluster of symptomswhich develop on total or partial withdrawal of alcohol intake after long use. Withdrawal state is one of the indicators of dependence syndrome. Alcohol withdrawal constitutes physical and psychological symptoms. Madatyaya (Alcoholism) is a similar condition where there is derangement of both Shareerika Dosha (Physical) and Manasika Dosha (Psychological). Hence a suitable Shamana Oushadi (Pacificatory drug) which acts upon both the body and mind would be an ideal choice. In Ayurvedic literature, Mrudveekadikashaya– a combination drug in decoction form,is specifically indicated in Trishna (thirst), Mrucha (syncope) Mada (intoxication), and Mativibhrama (Disorientation).These indications have striking similarities to that of symptoms seen in alcohol withdrawal. Therefore, an attempt was made to study the efficacy and pharmacological action of the combination drug on alcohol withdrawal symptoms. 37 diagnosed patients of Madatyaya (Alcohol Withdrawal symptoms) were registered as single group, for oral administration of Mrudveekadikashaya15ml thrice daily with lukewarm water before food for the period of one month. The patients were assessed by Clinical Institute Withdrawal Assessment for AlcoholRevised (CIWAAr) scale and Samanya Madatyaya Lakshanas (Ayurveda Parameters) before, during, after treatment. The results were analyzed statistically using SPSS VER.20. There was Statistical significant result in subjective symptoms of Madatyaya and Objective Parameters. Mrudveekadikashaya showed better results in the Management of Alcohol withdrawal symptoms and significant changes was observed in impaired liver functions.

EFFICACY OF MRUDVEEKADI KASHAYA IN THE MANAGEMENT OF MADATYAYA (ALCOHOL WITHDRAWAL SYMPTOMS)