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Bioactive novel imidazole derivatives have been synthesized under solvent free condition using molecular iodine as the catalyst and they are characterized by NMR spectra, X - ray, mass and CHN analysis. Their antioxidant potential were evaluated using different in vitro antioxidant models namely, DPPH (1,1 diphenyl - 2 - picryl hydroxyl) radical, s uperoxide anion and hydroxyl radical scavenging activities. The p - tolyl ring at C - 3 and p - fluorophenyl at C - 2 of the imidazole ring has maximum OH • (fpdmti) when compared with other imidazole derivatives. The low IC 50 value may be due to the electron donat ing (+I effect) ability exerted by the methyl substituent and electron withdrawing ( - I effect) ability exerted by the fluoro substituent. The 3,5 - dimethylphenyl ring at C - 2 of the imidazole ring (dmmppi) has maximum DPPH • and superoxide anion radical scave nging activities when compared with other imidazole derivatives and the low IC 50 value of dmmppi) may be due to the electron donating (+I effect) ability exerted by the two methyl substituent’s. Their antibacterial screening against Staphylococcus aureus , Escherichia coli and Klbesiella pneumoniae and antifungal activity against Aspergillus Niger, Aspergillus flavus and Candida - 6 were also evaluated.

ANTIOXIDANT POTENTIAL AND ANTIMICROBIAL SCREENING OF SOME NOVEL IMIDAZOLE DERIVATIVES