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Apigenin and oleanolic acid are secondary metabolite of Anredera cordifolia (Ten) V.Steenis . The plants are also recognized to have antihypertensive activities. Vasodilation is a major factor of cardiovascular function. The aim of the study is to determine the vasodilation and the mechanism of action of oleanolic acid and apigenin. The aortic rings were placed in an organ bath and precontracted with n orephineprine (2.9 x 10 - 3 mM), methyl ene blue followed by norephineprine (2.9 x 10 - 3 mM) and potassium chloride (40µM) for apart before addition of oleanolic acid (0.5µg/ml) and apigenin (0.05µg/ml). Anesthetized frog that exposed the heart was placed in an organ bath and precontracted with n orephineprine (2.9 x 10 - 3 mM) before addition of oleanolic acid (0.5µg/ml) and apigenin (0.05µg/ml). The vasodilation response in isolated rabbit aortic was evaluated through time duration to reach 100% relaxation and decreased of the heartbeat of the frog heart. Oleanolic acid (0.5µg/ml) produced significant vasodilation of the norephineprine pre - contracted rabbit aortic rings (p<0.05) but not with methylene blue followed with norephineprine. In addition, oleanolic acid not produced vasodilation with pre - c ontracted of potassium chloride. Moreover, oleanolic acid exhibited vasodilation of frog heart. While, for the apigenin (0.05µg/ml), it was produced vasodilation effect of the norephineprine, methylene blue followed by norephineprine an d potassium chlorid e pre - contracted rabbit aortic rings (p<0.05). Moreover, apigenin exhibited vasodilation of frog heart . In conclusion , oleanolic acid exhibited vasodilation through facilitating of nitric oxide (NO) and β 1 - adrenoreceptor inhibition. Whereas, the apigenin exhibited vasodilation effect through facilitating inhibition of calcium channel and β 1 - adrenoreceptor inhibition.

international journal of research in ayurveda and pharmacy

VASODILATION EFFECT OF OLEANOLIC ACID AND APIGENIN AS A METABOLITE COMPOUND OF ANREDERA CORDIFOLIA (TEN) V. STEENIS ON ISOLATED RABBIT AORTIC AND FROG HEART