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The serotoninergic system plays an essential role in the brain. Nerve cells that use serotonin as neurotransmitter are among the most branched and cross-linked. They are responsible for the modulation of several processes of the CNS. Therefore, the serotoninergic system is the target for the therapy of different diseases like depression, pain, schizophrenia and chemotherapy induced nausea and vomiting. Additionally, several drugs of abuse, like LSD, DMT, Mescalin and Psilocybin are acting directly on this system.

Investigation of the interaction between 5-HT3R and its modulators: progress in understanding the agonist binding site