English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The etiology of acne vulgaris is complicated and characterized by two aspects, non-inflammatory and inflammatory mechanisms. The non-inflammatory aspect is represented by follicular occlusion by sebaceous materials and resultant formation of comedo. On the other hand, acne features the continuing occurrence of inflammation, which yields reddish popular or nodular lesions. Therefore, acne is not a simple infection with Propionibacterium acnes, but subsequent inflammatory changes are the nature of acne. New quinolones, macrolides and tetracyclines are used for the treatment of acne as topical or systemic drugs. Recent accumulated evidence has suggested that these drugs exert their therapeutic effects by not only bacteriocidal actions but also anti-inflammatory or anti-immunological actions. These effects include antioxidative action toward neutrophils, inhibition of cytokine/chemokine production and adhesion molecule expression by keratinocytes, and suppression of the antigen-presenting ability of Langerhans cells. Drugs possessing these anti-inflammatory capacities are clinically beneficial for the treatment of inflammatory acne.

Anti-Microbial Therapies for Acne Vulgaris: Anti-Inflammatory Actions of Anti-Microbial Drugs in their Effectiveness