English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

In vitro, both acrylamide and bis-acrylamide inhibited the activity of purified creatine kinase (CK) from the human brain with almost the same potency. The inhibition was dose-dependent and non-competitive. In vivo, however, only acrylamide caused the splay of hind limbs and an awkward gait in rats, and inhibited CK activity in the brain. The CK activity of the regions of the brain investigated differed, and these distributions were well matched with those of human cases. The inhibition became more marked as the administration of acrylamide was repeated. While the distribution of 14C in the different regions of the brain did not differ after the injection of [14C] acrylamide, the degree of the suppression of CK activity differed in these regions and was most marked in the hypothalamus. Fifty-two-week-old rats appeared more susceptible to acrylamide than 8-week-old rats. However, no difference in the inhibition of the CK activity in the brain was noted between the older and the young ones. The possible relation of the regional differences of CK suppression with the pathogenesis of acrylamide encephalopathy is discussed.

The Suppression of CK Activity in the Brain by Acrylamide