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Descriptions were made in our previous papers, I and II, that the causative materials of four independent outbreaks of allergy-like food poisoning contained unusual amount of histamine and a vagusstimulant of unknown structure. The latter poison was successfully separated by oneand two-dimensional paper partition chromatography having been confirmed by Magnus' method using intestines of guinea pigs. The poison has been tentatively designated as •gsaurine•h by the authors, which was referred to •gsaury•h, Cololabis saira. •gSaurine•h is a basic substance and is insoluble in most of the organic solvents, and the hard-solubility in absolute alcohol is one of the differences from histamine. The wide distribution of •gsaurine•h in foodstuffs and the far much more amount of it in the incriminated foodstuffs when expressed in equivalent histamine may permit to regard it as the main agent of developing allergy-like symptoms in human beings« This paper deals with the physiological and pharmacological actions of this. •g saurine•h which would import a more profound significance to it as a causative agent in developing allergy-like symptoms.

japanese journal of medical science and biology/japanese journal of medical science and biology

STUDIES ON THE ALLERGY-LIKE FOOD POISONING ASSOCIATED WITH PUTREFACTION OF MARINE PRODUCTS III. PHYSIOLOGICAL AND PHARMACOLOGICAL ACTION OF ^|^ldquo;SAURINE^|^rdquo;, A VAGUSSTIMULANT OF UNKNOWN STRUCTURE RECENTLY ISOLATED BY THE AUTHORS, AND ITS CHARACTERISTICS IN DEVELOPING ALLERGY-LIKE SYMPTOMS