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Since the discovery of Koch's phenomenon and tuberculin by Koch1) and the introduction of a concept of allergy by Pirquet2), tuberculin skin test has been conducted as an indispensable tool for the diagnosis of tuberculous infection. The nature of this reaction, however, is not yet sufficiently explained, and we understand it only as a type of skin reaction in which antigen-antibody reaction may take a part in some unknown way. On the other hand, tuberculin allergy is considered as the most representative example of the hypersensitivity called •gbacterial or infectious hy-

OBSERVATIONS OF THE SKIN REACTION CAUSED BY A CYTOTOXIC IMMUNE SERUM IN COMPARISON WITH TUBERCULIN TEST IN GUINEA PIGS