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The term •gvirulence•h is generally used to represent the capacity of microorganisms to cause disease. This capacity is, however, determined by a number of different and independent factors in both sides of microorganisms and host. Therefore, if we hold the most inclusive view for the definition of virulence, we are compelled to use the expression •ghost-parasite relationship•h as suggested by Dubos1). As for tubercle bacilli, it has been often shown by several investigators2)3) 4)5) that their virulence is manifested in the degree of multiplication and survival

japanese journal of medical science and biology/japanese journal of medical science and biology

AN INTERFERENCE PHENOMENON BETWEEN VIRULENT AND AVIRULENT TUBERCLE BACILLI CONCERNING THEIR MULTIPLICATION AND SURVIVAL IN GUINEA PIGS, WITH SPECIAL REFERENCE TO THE MECHANISM OF VIRULENCE-ENHANCEMENT OF MYCOBACTERIAL STRAINS BY ANIMAL PASSAGE