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Injection of bovine serum albumin (BSA) heavily conjugated with dodecanoic acid, a saturated straight chain fatty acid, has been found to induce strong sustained delayed-type hypersensitivity (DTH) in guinea pigs. DTH was specific for BSA and was not accompanied with detectable immune response to the lipid moieties (Coon and Hunter, 1973). Since it was able to induce strong DTH and no detectable antibody production without using adjuvant , this lipidconjugated BSA (D-BSA) seems to be suitable for the investigation of regulatory mechanism involved in DTH. In this paper, we will report transient DTH, which was changed into sustained DTH by treatment with cyclophosphamide, induced by a single injection of lightly conjugated D-BSA and discuss possible presence of some suppressive mechanism for DTH. D-BSA preparations with different degrees of conjugation were obtained in manners similar to those described by Coon and Hunter (1973) and Dailey and Hunter (1974). The average number of fatty acids conjugated per BSA molecule is indicated by a subscript, e.g., D55BSA. Groups of five guinea pigs (Hartley strain , female, 350 to 500-g weight) were injected intradermally in the rear footpads with D-BSA in 0 .1 ml of PBS

japanese journal of medical science and biology/japanese journal of medical science and biology

TRANSIENT DELAYED-TYPE HYPERSENSITIVITY INDUCED BY LIGHTLY LIPID-CONJUGATED BSA AND ITS CONVERSION INTO SUSTAINED NATURE BY CYCLOPHOSPHAMIDE TREATMENT IN GUINEA PIGS