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The demonstration by Andrewes and Carmichael (1930) that a majority of human population possessed antibodies against herpes virus opened a way to a number of follow-up investigations, and the total body of data accumulated has supported the essence of the postulate of Burnet and Williams (1939) that the primary infections, either apparent or inapparent, might occur mostly in childhood and result in a commensal host-parasite relation lasting for the rest of life with or without occasional manifestations such as recurrent herpes. The earlier workers, employing neutralization test (Weyer, 1932; Burnet and Lush, 1939; Scott et al., 1952; Buddingh et al., 1953; Tateno et al., 1958), complement fixation test (Hayward, 1950: Holzel et al., 1953; Yamaguchi, 1959a) or both (Dascomb et al., 1955; Yamaguchi, 1955b; Schmidt and Lennette, 1961), found antibodies among 60 to 100 per cent of the adult populations examined. It was also a common observation that newborn babies less than four months old showed the same positive ratio as adults but after this period a

A SEROLOGICAL SURVEY FOR ANTIBODIES AGAINST HERPES SIMPLEX VIRUS WITH SPECIAL REFERENCE TO COMPARATIVELY HEAT-LABILE COMPLEMENT-FIXING ANTIBODIES