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In a series of investigations with CM*-resistant strains of E, coli, we have considered the mechanism of resistance as relevant to the following three possibilities: (I) alteration of metabolism, (II) inactivation of CM, and (III) changes in the permeability. Investigations were made on the possibilities (II) and (III) in the preceding papers (Okamoto, 1959a; Hirokawa et al., 1959). The present report is concerned with the possibility (I). The primary action of CM on bacterial cells is known to be an inhibition of protein biosynthesis (Wisseman et al., 1954). Obviously, however, CMR strain can synthesize protein and produce induced enzyme in the presence of CM. If CMR cells escape from the action of CM by altering its metabolism according to the possibility (I), it might be expected that the protein(s) synthesized by CMR cells differ(s) from that synthesized by sensitive cells. In an attempt to elucidate this possibility we examined and compared the following two properties of bacterial proteins; (1) the electrophoretical pattern of the induced enzyme ƒÀ-galactosidase formed by sensitive and CMR strains, (2) the total amino acid composition of the bacterial cells of both strains. Contrary to the above expectation, no significant difference was observed in these properties between the sensitive and resistant strains.

japanese journal of medical science and biology/japanese journal of medical science and biology

MECHANISM OF CHLORAMPHENICOL RESISTANCE IN E. COLI III. THE TOTAL AMINO-ACID COMPOSITION OF CHLORAMPHENICOL RESISTANT E. COLI AND ELECTROPHORETICAL PATTERN OF ITS ^|^beta;-GALACTOSIDASE