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It is well known since Hippocrates that orchitis is one of the complications in mumps. Mohr (1), Nagel (2), Flaum (3) and H. J. John (4) advocated the theory of explaining the salivary glands as internal secretory organs after recognizing clinically that hypertrophy of parotid glands is a common symptom in hormonal diseases, but their theory was based merely on few case-reports and lack experimental criteria. Furthermore, Goljanitzki (5), Mansfeld (6), Uchitnura (7) and Ogata (8) discussed the theory of internal secretion of salivary glands, illustrating the results of their animal experiments, but it must be noted there are many discrepancies in their results. Accordingly, it can be assumed that no one has yet established the theory of internal secretion of salivary glands both clinically and experimentally. Because of extreme shortage of insulin in Japan during 1946, Takaoka applied, instead of insulin treatment, X-ray irradiation on thyroid glands of diabetic patients. In February 1947, Takaoka noticed for the first time the symmetrical and non-inflammatory swelling of bilateral parotid glands in a young diabetic patient whose symptom was exacerbated during the daily irradiation. After observing the similar hypertrophy of parotid glands of two other diabetics successively in March and May, we started to make a research on the theory of internal secretion of salivary glands. This report is to describe the gist of our research. 1. Results of palpation of parotid glands Methods of the palpation of the parotid glands is to hold the subcutaneous tissue directly under the ear-lobe by thumb and forefinger as seen in Photo 1 and to close the space between two fingers carefully. Then the peculiar hardiness of the parotid glands can be feft deep inside therein. Up to now total number of persons examined by this method is 3,638. With the exception of inten sive edema or tumor infiltration there is no difficulty in palpation. When parotid glands may be palpable only on one side, we take it, too, as positive parotid glands. Result of the palpation on 2,276 normol individuals disclosed that approximately 15 per Patho 1 Palpation of parotid gland

HYPERTROPHY OF PAROTID GLANDS IN DIABETES MELLITUS AND INTERNAL SECRETION OF SALIVARY GLANDS