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We evaluated interleukin-10 (IL10) 592 C/A, IL4589 C/T, interferon gamma (IFNG)874 A/T, cytotoxic T-lymphocyte-associated antigen 4 (CTLA4)49 A/G gene polymorphisms associated with efavirenz hypersensitivity reaction. A total of 63 human immunodeficiency virus-positive patients under treatment at a public hospital were included in the study, of whom 21 presented with efavirenz hypersensitivity. Patients who presented with efavirenz hypersensitivity reaction showed a higher frequency of the IL10 592A allele than the controls (p0.028). The allele A was associated with increased risk of efavirenz hypersensitivity (odds ratio2.40). In case of IL4, a significant difference in the frequency of the IL4 589 (C/T) polymorphism was not observed between patients and controls. A significant inverse correlation was observed when comparing the CTLA449A/G and IL4 589 C/T polymorphisms (r0.650, p0.001); that is, the CTLA4 +49GG genotype, involved with the lowest capacity of inhibition, was inversely correlated IL4589TT genotype, which induces high production of IL-4. With respect to the CTLA449A/G and IFNG874T/A gene polymorphisms, significant differences in allele and genotype frequencies were not observed between the groups. Therefore, our data suggest that polymorphisms in regulatory regions of cytokine genes could modulate an individual's susceptibility to efavirenz hypersensitivity reaction.

japanese journal of infectious diseases

Association of <i>IL10, IL4, IFNG</i>, and <i>CTLA4</i> Gene Polymorphisms with Efavirenz Hypersensitivity Reaction in Patients Infected with Human Immunodeficiency Virus

Association of IL10, IL4, IFNG, and CTLA4 Gene Polymorphisms with Efavirenz Hypersensitivity Reaction in Patients Infected with Human Immunodeficiency Virus