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The in vitro activity of linezolid was evaluated against 84 clinical isolates of  Mycobacterium tuberculosis, including multidrug-resistant (MDR) and extensively drug-resistant  (XDR) strains, isolated from the center for tuberculosis research and treatment of the Chinese  army. Linezolid showed excellent activity, with minimum inhibitory concentrations (MICs) of  0.125-0.5 μg/mL against all tested isolates. There were no differences in the MIC(50) and MIC(90)  of linezolid between susceptible, isoniazid-resistant, MDR, and XDR. Indeed, all of the groups  displayed identical MIC(90) values of 0.25 μg/mL, which is lower than previously reported in  similar studies. We conclude that linezolid may be a more effective drug against M. tuberculosis  and may play an important role in treating drug-resistant tuberculosis in China.

japanese journal of infectious diseases

In Vitro Activity of Linezolid against Clinical Isolates of Mycobacterium tuberculosis, including Multidrug-Resistant and Extensively Drug-Resistant Strains from Beijing, China