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Introduction: Dengue virus infection has emerged as a notable public health problem in recent decades in terms of the mortality and morbidity associated with it. Dengue has become endemic in India with outbreaks occurring almost every year. Aim: This study is to correlate the clinical marker like platelet count and serological markers like IgM and NS1 in the acute stage of dengue infection Materials and Methods: This was a cross-sectional study of conducted in the Government Hospital, Jamnagar, India, the primary health care centres and the community health care centres, which were covered under the district Jamnagar, all clinically suspected cases of dengue, reported to various outpatient departments, emergency services and admitted patients in our Hospital, were included for this study, between the period of September 2013 to December 2013 over duration of 4 months. Samples from clinically suspected dengue cases were collected and tested for NS1 and IgM by ELISA depending on days of fever. Platelet counts were obtained from all positive cases. In all positive cases dengue specific parameters like NS1 and IgM were compared against platelet counts. Statistical Analysis: The Chi-Square test and statistical software Epi info and MS excel was used to find out the statistical significance of the estimate. Results: Of 1628 samples tested, 563 were positive for one or more dengue parameters. Of the 563, 363 were positive for NS1 only, 200 were positive for IgM only, Thrombocytopenia was more consistently associated whenever IgM was detected compared to NS1 detection. Conclusion: Inclusion of NS1 in the diagnosis of dengue increases the early diagnosis so as to avoid complications significantly. In confirmed dengue cases with fever, thrombocytopenia is more consistently found whenever IgM is positive compared to NS1 positive and can be used as predictor to reduce the morbidity and moratlity of dengue disease. InTROduCTIOn Dengue fever is an acute febrile arbo-viral disease affecting the tropical and subtropical regions of the world. The incidence of this disease has increased over the last 50 years with 2.5 billion people living in areas where dengue is endemic [1]. Severe and potentially lethal type of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are found more in children now-a-days increasing disease burden [2]. DHF with mortality in most countries is 5%, primarily among young children and adults [3]. Rapid and sensitive laboratory methods required for early detection of the disease to reduce the morbidity and mortality [4]. More specific methods like virus isolation, genomic RNA detection by PCR, antigen and antibody detection by ELISA are available but it needs well trained staff and an expensive setup which is not feasible in peripheral hospital settings [5]. In most cases antibody (IgG/M) detection are commonly used for diagnosis of dengue infection, but time required for appearance of IgM antibody is approximately 4-6 days [6]. Dengue non-structural 1 antigen (NS1) is highly conserved glycoprotein produced in both membrane associated and secretory forms is used as a new biomarker for early diagnosis of dengue infection [7]. NS1 antigen detected by ELISA is present in high concentrations in sera of dengue virus infected patients during early clinical phase of disease [8]. Apart from dengue specific parameters, platelet count is M ic ro b io lo g y S ec tio n

Study of Correlation Between Platelet Count and Serological Markers of Dengue Infection with Importance of NS1 Antigen in Western Region of India