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Foeniculum vulgare seed is used to treat infertility because of phytoestrogenic properties.  Aim: The present study was conducted to compare the effects of F. vulgare plus oestrogen and oestrogen alone on Endometrial Thickness (ET) in infertile women.  Materials and Methods: In this study, 92 people with infertility were enrolled by convenience sampling and randomly divided into case (45 women) and control (47 women) groups. Both groups were administered with oestradiol valerate 2 mg tablet three times a day since the third day of the menstrual cycle. Treatment group was also administered with F. vulgare tea on a daily basis. Then, ultrasound was conducted once every three days to determine ED. Other data such as serum beta-hCG level and increase in oestrogen dose were recorded in a checklist. The data were analysed by independent t-test and Chi-square in SPSS version 17.0.  Results: There were no significant differences in mean age, BMI, number of years of infertility, number of children, cause of infertility, positive beta-hCG, failure to achieve adequate endometrial thickness, and increase in oestradiol dose between the treatment and control groups (p>0.05). The mean number of days to achieve ET of at least 8 mm was 13.1 +/- 3.2 in the treatment group and 14.2 +/- 3.5 in the control group with no significant difference (p>0.05).  Conclusion: F. vulgare seed tea was not significantly effective in increasing the ET as compared to oestradiol valerate 6 mg alone.

Comparison of the Effect of Oestrogen Plus Foeniculum vulgare Seed and Oestrogen alone on Increase in Endometrial Thickness in Infertile Women