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*Jeollanamdo Development Institute of Korean Traditional Medicine, Jangheung 529-851, Korea.**Research Institute, Gyeongsangnam-do Agricultural Research & Extension Services, Changwon 641-920, Korea.***Namhae Sub-Station, NIHHS, RDA, Namhae 668-812, Korea. ABSTRACT : Dendrobium moniliforme (DM) is a valuable and versatile herbal medicine with the anecdotal claims of anti-oxidant and anti-inflammation. In the present study, we investigated the whitening and anti-wrinkling effects of DM undervarious conditions with B16F10 melanoma cells and human dermal fibroblasts. The DM extract inhibited melanin contentsand tyrosinase activity in a dose-dependent manner, compared with untreated group. Treatment of the DM extract effec-tively suppressed the α-MSH-stimulated melanin formation, tyrosinase activity and dendrite outgrowth. Moreover, the α-MSH-induced mRNA expressions of tyrosinase-related protein-1 (TRP-1) and tyrosinase-related protein-2 (TRP-2) andprotein expression of tyrosinase were significantly attenuated by DM treatment. We also investigated the DM increased theproduction of type I procollagen and inhibited TNF- α-induced mRNA expressions of MMP-1, -3 in the human dermal fibro-blast. These results indicate that DM may be a great cosmeceutical ingredient for its whitening and anti-wrinkle effects.Key Words : Whitening, Anti-wrinkling, Dendrobium moniliforme, Melanin, Tyrosinase

Whitening and Anti-wrinkle Effects of Korean Native Dendrobium moniliforme Methanol Extract