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*The Clinical Trial Center for Bio-Industry, Semyung University, Jecheon 309-711, Korea.**Oriental Medicine, Semyung University, Jecheon 309-711, Korea. ABSTRACT : Paeoniae Radix Rubra is a preparation consisting of desiccated roots of Paeonia lactiflora PALL (belonging toRanunculaceae). Paeoniae Radix Rubra is used as a medicinal herb in Asian countries to treat many diseases. Ethanol- orwater-based extracts of Paeoniae Radix Rubra were prepared and tested on RAW 264.7 cells, a murine macrophage cell line.The expression of some pro-inflammatory proteins, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2(COX-2), extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphorylated ERK1/2 was detected by Western blotanalyses, while PGE2 expression was quantified by ELISA. Both the water and ethanol extracts of Paeoniae Radix Rubrasuppressed LPS-induced nitric oxide (NO) production and exhibited cell toxicity in accordance with increased NO produc-tion. Also, both extracts reduced the expression of COX-2 and iNOS, and inhibited phosphorylation of ERK1/2 in LPS-stim-ulated RAW 264.7 cells. Extracts prepared from Paeoniae Radix Rubra contain anti-inflammatory agents that inhibit theiNOS and MAPK pathways.Key Words : Paeoniae Radix Rubra, iNOS, COX-2, ERK1/2, PGE2

Suppression Effect of the Inflammatory Response in Macrophages by Paeoniae Radix Rubra Extracts