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The use of current antiepileptic drugs has been questioned due to their non selectivity and undesirable side effects. In pursuit of better anticonvulsant drug and the significance of semicarbazones as anticonvulsant pharmacophore, a series of novel benzimidazole substituted semicarbazones were designed, synthesized and evaluated for their anticonvulsant activity. Semicarbazones based benzimidazole analogues are hitherto unreported for their promising anticonvulsant activity. The synthesized molecules were characterized using elemental and spectral (IR, 1 H NMR, 13 C NMR and MS) analysis. The anticonvulsant activities of the compounds were investigated using maximal electroshock seizure (MES) model. The rotarod test was employed for neurotoxicity evaluation. Efforts were also made to establish structure-activity relationships among synthesized compounds. The results of these investigations confirmed that the pharmacophore model with four binding sites is vital for antiepileptic activity.

Synthesis and Evaluation of Some Novel Semicarbazones Based Benzimidazole Derivatives as Anticonvulsant Agent