English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Severe traumatic brain injury (TBI) is a leading cause of death and disability. Not all neuronal damage occurs at the time of primary injury, but rather TBI initiates a cascade of events that leads to secondary brain injury. Oxygenation is one crucial factor in maintaining brain tissue homeostasis post-injury. We performed a retrospective review of patients admitted to a single trauma center after TBI. Statistical analysis was performed to ascertain if the measured partial pressure of oxygen (PaO₂) affected overall outcome at the time of discharge from the hospital.  Materials and Methods  Statistical analysis was performed retrospectively on patients admitted with a Glasgow Coma Scale (GCS) < 8 and a diagnosis of TBI. GCS and Glasgow Outcome Scale (GOS) were calculated from physical examination findings at the time of hospital discharge or death. Patient data were separated into two groups: those with consistently higher average PaO₂ scores (≥ 150 mmHg; n = 7) and those with lower average PaO₂ scores (< 150 mmHg; n = 8). The minimum requirement to be categorized in the consistently higher group was to have an average hospital day 1 through 5 PaO₂ value of ≥ 150 mmHg.  Results  Patients with consistent hospital Day 1 through 5 PaO₂ scores of ≥ 150 mmHg had statistically significant higher GCS scores at the end of intensive care unit (ICU)-level care or hospital discharge (mean = 12,  p  = 0.01), compared to those in group 2 with lower PaO₂ levels (mean = 7.9). There was no statistically significant difference in GOS when comparing the two groups ( p  = 0.055); however, the data did show a trend toward significance.  Discussion and Conclusion  In our study we analyzed patients diagnosed with TBI and stratified them into groups based on PaO₂ ≥ or < 150 mmHg. We demonstrate overall outcome improvement based on GCS with a trend toward improved GOS. The GCS showed statistical significance in patients with PaO₂ consistently ≥ 150 mmHg versus those in group 2 over the first five days of hospitalization.

Optimal Partial Pressure of Oxygen Affects Outcomes in Patients With Severe Traumatic Brain Injury