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Background  Early diagnosis and accurate assessment of the severity of the disease are critical factors in the management of acute pancreatitis (AP). In this study, we investigated the success rates of combinations of Bedside Index of Severity in Acute Pancreatitis (BISAP) scores with C-reactive protein (CRP) values in predicting severe AP.  Methods  The medical records of all patients with AP admitted to our hospitals from September 2015 to September 2018 were reviewed retrospectively. To evaluate the severity of AP, the revised Atlanta criteria were used, and patients who developed organ failure lasting more than 48 hours were considered to have severe AP. We analyzed patient CRP values at the 24-hour mark via receiver operating characteristic (ROC) curve analysis. Four groups were then formed to separate mild AP from moderate to severe AP. The first group had BISAP scores ≥ 3, the second group had CRP values ≥ 90.7 mg/L, the third group had BISAP scores ≥ 3 and CRP values ≥ 90.7 mg/L, and the fourth group had BISAP scores ≥ 3 or measured CRP values ≥ 90.7 mg/L. Predictive accuracy, sensitivity, specificity, and positive and negative predictive values of groups in the prediction of severe AP were calculated.  Results  Our study population consisted of 207 patients, and according to the revised Atlanta scoring, 165 patients (79.7%) had mild AP, 30 (14.4%) had moderate, and 12 (5.8%) had severe AP. Comparing the mild, moderate, severe AP groups, we noted a significant difference between the mean hospital stay time, BISAP scores, and CRP values (p<0.001). Group 1, 2, 3, and 4 values of mild AP and all severe AP (moderate and severe) were significant (p<0.001). The highest specificity values were found in Group 3 (97.6%), while the highest sensitivity values were observed in Group 4 (88.1%).  Conclusion   CRP may increase the success of BISAP scoring in predicting the severity of AP.

Can C-reactive Protein Increase the Efficiency of the Bedside Index of Severity in Acute Pancreatitis Scoring System?