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Epstein-Barr Virus (EBV) infection has a diverse spectrum of clinical presentations. We encountered a previously healthy young female adult with positive EBV Viral Capsid (VCA)-IgM serology and heterophile antibodies who presented with abdominal pain, mesenteric adenitis, and elevated liver enzymes without the more common manifestations of EBV infection. A review of the clinical and laboratory manifestations of EBV infection is provided, focusing on the association between EBV infection and elevated liver enzymes and abdominal pain.

An Uncommon Presentation of a Common Illness: Epstein-Barr Virus (EBV) Infection Case Report and Review of Literature