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Postoperative hyponatremia is common. It results from the physiological antidiuretic hormone (ADH) response to surgery and associated exacerbating factors. Common exacerbating factors include medications, excessive fluid administration, and syndrome of inappropriate antidiuretic hormone (SIADH) secretion. High-dose trimethoprim can cause transient salt-losing nephropathy, resulting in SIADH-like hyponatremia associated with hypovolemia, hyperkalemia, and metabolic acidosis. We present a patient who developed symptoms of vomiting, loss of appetite, fatigue, and abdominal discomfort six days after having a transurethral bladder wall biopsy. He had also started a course of trimethoprim two days prior to the onset of the symptoms. Initial investigations demonstrated severe hyponatremia, concentrated urine, and compensated metabolic acidosis. These results suggested postoperative SIADH possibly exacerbated by trimethoprim-related hyponatremia. Cautious IV normal sodium chloride infusion resulted in a rapid recovery. While raising the awareness of postoperative hyponatremia, this case also highlights the difficulty distinguishing between SIADH and trimethoprim-related hyponatremia.

Syndrome of Inappropriate Antidiuretic Hormone Secretion and Trimethoprim-Related Hyponatremia Following Transurethral Bladder Wall Biopsy