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Meralgia paresthetica, a condition characterized by tingling, numbness, and burning pain in the lateral aspect of the thigh, is caused by compression of the lateral femoral cutaneous nerve. The incidence of meralgia paresthetica increases with obesity and diabetes. The unique anatomy of the nerve that tunnels through the inguinal ligament predisposes it to inflammation, trauma, and entrapment. The pathology of meralgia paresthetica parallels that of entrapment neuropathies but with additional inflammatory overlay in certain instances. The clinical diagnosis is relatively simple due to its unique clinical features. The prognosis is generally excellent, and the treatment is straightforward that includes peripheral nerve blocks, neurectomy, nerve decompression, and pulsed radiofrequency neuromodulation. This current case of meralgia paresthetica highlights the salient clinical symptoms and signs. We have also described the electrophysiological studies of the lateral femoral cutaneous nerve, its anatomical variations, and the associations of meralgia paresthetica with bariatric surgery, critical care patients, tight clothing, pregnancy, and posterior spine surgery. We have also outlined the current treatment strategies.

Meralgia Paresthetica: A Case Report With an Update on Anatomy, Pathology, and Therapy