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Hemolytic uremic syndrome (HUS) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. HUS can be secondary to multiple etiologies such as infections, medications, and immune processes. A rare, yet significant, etiology of HUS includes acute  Clostridium difficile  colitis. Here, we present a case of atypical HUS secondary to acute  C. difficile  colitis, successfully treated with hemodialysis and systemic corticosteroids. It is imperative that clinicians are cognizant of  C. difficile -associated HUS given the overall rising incidence of acute  C. difficile  infections.

Atypical Hemolytic Uremic Syndrome in the Setting of Acute Clostridium difficile Colitis