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This study investigated DNA damage protection and anti-inflammatory activity of different solvent fractions from Aruncus dioicus var. kamtschaticus (A. dioicus) aerial parts water extract. As for DNA damage protection, distilled water (H2O) fraction displayed the most powerful protection for DNA damage at a concentration of 1 ㎎/㎖. As for anti-inflammatory activity, dichloromethane (CH2Cl2) fraction exhibited the highest NO inhibition activity, ranging from 61% to 19% (10-40 ㎍/㎖). Furthermore, the levels of pro-inflammatory cytokines mRNA expressions and intracellular reactive oxygen species (ROS) were employed to verify the anti-inflammatory activity of the CH2Cl2 fraction on further researches. It could be concluded that A. dioicus had a significantly effect of DNA damage protection and anti-inflammatory activity which also as an essential edible vegetable and medicinal species.

DNA Damage Protection and Anti-inflammatory Activity of Different Solvent Fractions from Aruncus dioicus var. kamtschaticus