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Effects of Korean Herbal Bathing Extracts Composition on Th2 Cytokine Production in MC/9 Mast Cells Moon-Hee Jang  † , Jae-Song Choi  † , Ae-Ryun Choi  * , and Taek-Won Ahn  † Dept. of Sasang Constitutional Medicine, College Oriental Medicine, Daejeon Univ.  Dept. of Sasang Constitutional Medicine, College Oriental Medicine, Daegu Haany Univ. † Hot Spring Medicine Laboratory, College Oriental Medicine, Daejeon Univ.ObjectivesThe purpose of this study is to investigate the effects of korean herbal bathing extracts composition 1 and composition2 on Th2 cytokine production in MC/9 mast cells. MethodsThe effects of composition 1, 2 was analyzed by ELISA and Real-time PCR in MC/9 mast cells. Levels of IL-5, IL-13 were measured using enzyme-linked immunosorbent assays(ELISA). mRNA levels of IL-4, IL-5, IL-6, IL-13 were analyzed with Real-time PCR.ResultsComposition 1, 2 inhibited the IL-5, IL-13 production signifcantly(p<.001) in comparison to PI-control group at concentrationof 100 ㎍/mL, 200 ㎍/mL. Composition 1, 2 inhibited the IL-4, IL-5, IL-13 mRNA expression signifcantly in comparison to PI-control group at concentration of 100 ㎍/mL, 200 ㎍/mL. Composition 1 inhibited the IL-6 mRNA expression significantl yin comparison to PI-control group at concentration of 200 ㎍/㎖. Composition 2 inhibited the IL-6 mRNA expression significantl y in comparison to PI-control group at concentration of 100 ㎍/mL, 200 ㎍/mL.ConclusionsThese results indicate that composition 1, 2 has the effect of decreasing the Th2 cytokine production in the MC/9 mast cell.Key Words: Korean Herbal Bathing Extracts Composition, Cytokine, MC/9 Mast Cell, Atopic Dermatitis.