English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

MicroRNA-146a (miR-146a) has been demonstrated as a tumour-suppressor in different malignancies including prostate cancer. As an endogenous small RNA, miR-146a regulates several gene expressions at the post-transcriptional level. Previous studies indicate that miR-146a is highly expressed in normal prostate tissue and significantly down-regulated in prostate cancer tissue and even worse in castration-resistant prostate cancer (CRPC) tissues. Over-expression of miR-146a in prostate cancer cell lines results in a marked reduction of cell proliferation, invasion and tumorigenesis. However, the regulating mechanism of miR-146a expression in the different stages of prostate cancer remains unclear. Yin Yang 1 (YY1), a critical regulator in prostate cancer development and progression, is predicted to be a direct target of miR-146a and binds to the promoter region of miR-146a, which is partly confirmed by the inverse expressions of miR-146a and YY1 in prostate cancer. Therefore, we hypothesize that YY1-miR-146a-YY1 regulatory circuitry contributes to prostate cancer and may serve as a future intervention target

YY1-miR-146a-YY1 Regulatory Circuitry: A Potential Mechanism of Prostate Cancer Formation and Progression