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Objective: Several natural supplementations have been investigated over centuries for a wide variety of ailments. There is limited information available on the effect and safety of these natural supplementations on patients with high risk coronary artery disease. We aim to evaluate the results of garlic and lemon therapy via clinical and angiographic outcomes in patients with ST-elevation myocardial infarction. Methods: Patients who had >70% non-culprit coronary stenosis were included in the study. Patients who underwent optimal medical therapy were randomized to the treatment. At the end of the followup, patients were evaluated in terms of clinical and angiographic outcomes. Results: Of the 77 subjects enrolled in the study, fifty-eight patients (28 from the treatment group and 30 from the control group) completed the study period successfully. During the follow-up period, the need for early revascularization appeared later in the treatment group as compared to the control group. According to the Rose angina survey, the rates of definite angina, and probable angina were lower in the treatment group compared to the control group. The mean stenosis, in the treatment group, at the baseline and that in the 3 month was 49.32±20.45 and 48.48±20.64, respectively (p = 0.168); whereas, in the control group, it was 49.93±22.71 and 49.14±22.63, respectively (p = 0.116). Conclusion: Based on the present study, no significant change was observed in atherosclerotic plaques at the end of the three-month treatment period, although it resulted in symptomatic benefits. However, the absence of serious adverse events within the 3-month period is important as it suggests the safety of the treatment.

Evaluation of Garlic-Lemon Therapy on Clinical and Angiographic Outcomes in Patients with High Risk Acute Coronary Syndrome