English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Calcineurin (CN) is known to be involved in many biological processes, particularly, the immune response mechanism in many invertebrates. In this study, we characterized both  HcCNA  and  HcCNB  genes in  Haliotis diversicolor , documented their expression in many tissues, and discerned their function as immune responsive genes against  Vibrio parahaemolyticus  infection. Similar to other mollusk CNs, the  HcCNA  gene lacked a proline-rich domain and comprised only one isoform of its catalytic unit, in contrast to CNs found in mammals. HcCNB was highly conserved in both sequence and domain architecture. Quantitative PCR and in situ hybridization revealed that the genes were broadly expressed and were not restricted to tissues traditionally associated with immune function. Upon infection of  H. diversicolor  with  V. parahaemolyticus  (a bacteria that causes serious disease in crustaceans and mollusks), both  HcCNA  and  HcCNB  genes were highly up-regulated at the early phase of bacterial infection.  HcCNB  was expressed significantly higher than  HcCNA  in response to bacterial challenge, suggesting its independent or more rapid response to bacterial infection. Together, the two  CN  genes are unique in their gene structure (particular  HcCNA ) and distribution in mollusk species and likely function as immune responsive genes along with many other genes that are enhanced in the early phase of  V. parahaemolyticus  infection in abalone.

Characterization of calcineurin A and B genes in the abalone, Haliotis diversicolor, and their immune response role during bacterial infection