English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

We present a meta-analysis of independent studies on the potentialimplication in the occurrence of coronary heart disease (CHD) of thesingle-nucleotide polymorphism (SNP) at the -308 position of the tumor necrosisfactor alpha (TNF-alpha) gene. We use Bayesian analysis to integrateindependent data sets and to infer statistically robust measurements ofcorrelation. Bayesian hypothesis testing indicates that there is no preferencefor the hypothesis that the -308 TNF-alpha SNP is related to the occurrence ofCHD, in the Caucasian or in the Asian population, over the null hypothesis. Asa measure of correlation, we use the probability of occurrence of CHDconditional on the presence of the SNP, derived as the posterior probability ofthe Bayesian meta-analysis. The conditional probability indicates that CHD isnot more likely to occur when the SNP is present, which suggests that the -308TNF-alpha SNP is not implicated in the occurrence of CHD.

Integrated probability of coronary heart disease subject to the -308 tumor necrosis factor-alpha SNP: a Bayesian meta-analysis