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Human dermatitis caused by the bite of the larval trombiculid mite, Leptotrombidium scutellare, was observed by exposing a larva to the skin of a volunteer. Twenty four hours a er the bite, a small erythematous macule with itching developed and expanded by 72 hours. e skin lesion gradually improved and had almost disappeared 2 weeks later. Histopathological study of the erythematous macule 48 hours a er the bite showed in ammatory in ltrates consisted of lymphocytes in the upper dermis. Immunohistochemically, most lymphocytes in the upper dermis were CD3positive and CD20-negative. ese results suggest that the dermatitis caused by the bite of larval Leptotrombidium scutellare was induced by delayed-type hypersensitivity to saliva substances.

Clinical and histopathological study of dermatitis caused by experimental bites of the larval trombiculid mite, Leptotrombidium scutellare