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The effects of a 70% methanolic extract and its fractions obtained from Eleutherococcus, and effects of exercise on oxidative enzyme activity in skeletal muscle, superoxide dismutase activity and lipid peroxidation were studied for 6 weeks using male ICR mice. At the age of 11 weeks, 70 mice were divided into six groups: a non-exercise group (control), a group administered the 70% methanolic extract (MeOH), a group administered a water-soluble extract (water), a group administered an n-BuOH extract (n-BuOH), a group administered an EtOAc extract (EtOAc) and a group given running exercise (exercise). Eleutherococcus extracts were given p, o, at 170 mg/kg per day (6 days/week) for 6 weeks. After 6 weeks of training (1 h/day, 6 days/week at 15 m/min, on a flat floor without any slope), succinate dehydrogenase (SDH) activity in gastrocnemius muscle was increased significatly in the exercise group compared with the control group. SDH activity showed an increasing tendency in groups given Eleutherococcus extracts compared with the control group (n-BuOH>water>MeOH>EtOAc>control). Malate dehydrogenase (MDH) activity in the exercise group was significantly different from that in the control group at P<0.005. In the water and n-BuOH groups, MDH activity was significantly greater than in the control group, whereas an increasing tendency was shown in the McOH and EtOAc groups. Muscle superoxide dismutase (SOD) activity in the exercise, McOH, water and n-BuOH groups was signif icantly greater than in the control group, and hepatic SOD activity was slightly higher in the exercise, McOH and water groups in comparison with the control group, although these dif ferences were not significant. After endurance training, hepatic lipid peroxidation (LPO) was decreased by 17% in the exercise group. In the n-BuOH and EtOAc groups, a significant de crease was observed in hepatic LPO. These results suggest that endurance training and administration of Eleutherococcus ex tracts enhance the activities of oxidative enzymes in skeletal muscle and also SOD in mice, resulting in improved aerobic metabolic rates, and also might intensify the functions of the host defense system against injury caused lipid peroxidation. (Jpn. J. Phys. Fitness Sports Med. 1992, 41: 304-312) key words: Eleutherococcus, Oxidative enzyme activity, Superoxide dismutase, Lipid per oxidation, Endurance training *岐阜大学医学部衛生学教室 〒500岐阜市司町4幡 地 岐阜薬科大学保健体育学教室 〒502岐阜市三田洞東5丁 目6-1 Department of Hygiene, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500, Japan Department of Health and Physical Education, Gifu Pharmaceutical University, 6-1, Mitahora-higashi 5 chome, Gifu 502, Japan エゾウコギがマウス骨格筋酸化系酵素活性およびSOD活 性と組織中の過酸化脂質に及ぼす影響305

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EFFECTS OF &lt;I&gt;ELEUTHEROCOCCUS&lt;/I&gt; EXTRACTS ON OXIDATIVE ENZYME ACTIVITY IN SKELETAL MUSCLE, SUPEROXIDE DISMUTASE ACTIVITY AND LIPID PEROXIDATION IN MICE