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The effects of maternal physical exercise during eary pregnancy upon the embryonic development of mice were studied as follows : A/Jax female mice at 10 to 16 weeks of age were imposed daily compulsory running at the speed of 15 meter/mm. using a tread mill for 100 min. for the period from zero to 6th day of gestation (called severe exercise group) and for 50 min. from zero to 13th day of gestation (called mild exercise group) respectively. All mice together with the control group without the exercise were sacri ficed at 18th day of gestation and the states of concep.uses as well as external and skeletal development of fetuses were observed. The results may be summarized as follows 1.Significant pregnancy-blocking effect was found in the severe exercise group and it is presumed that the treatment caused obstruction of implantation or maintaince of early pregnancy after implantation in most cases. 2. No significant differences were observed in litter size, fetal mortality, fetal body weight and frequency of the malformed fetuses between pregnant mothers of each of experimental group and control group. 3. The progress of ossification in the mild exercise group was slightly superior in some part of the skeleton to that of the control group.

EFFECTS OF SEVERE MATERNAL PHYSICAL EXERCISE DURING EARLY PREGNANCY UPON THE DEVELOPMENT OF MOUSE EMBRYOS