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Ethyl pyridine-4-carboxylate (1) treated with hydrazine hydrate in methanol give pyridine-4-carboxy hydrazide (2). Compound 2 react with substituted aroyl chlorides affords N-substituted aroyl pyridine-4-carbonyl hydrazines (3-9), which on treatment with POCl3 yield 2(substituted phenyl)-5-(pyridine-4-yl)-1,3,4-oxadiazoles (10-16). The newly synthesized compounds 10-16 were confirmed by elemental (C, H, N) and spectral (IR, H NMR and mass) analysis. Compounds 10-16 have been tested for their antibacterial activity using ampicillin as a reference compound.

Synthesis and Antibacterial Activity of 2-(Substituted phenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazoles