English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A series of novel 3-(2-chloroquinolin -3- yl)acrylic acid derivatives (3a-j) were prepared by Knoevenagal condensation of 2-chloro 3-formyl quinoline (2a-j) with malonic acid (2) in the presence of catalytic quantity of pyridine under microwave irradiation in excellent yield with short time span (70 s). Newly synthesized compounds were characterized by IR, 1 H NMR and mass. activity 17 . Derivatives of 3-(quinolin-3-yl)acrylates and the corresponding reduced allylic alcohols that have been identified by Bristol-Myers Squibb (BMS) as novel and potent maxi-K channel openers useful for the treatment of male erectile dysfunction 18 . Due to such a wide range of applicability in medicinal field, there is increasing interest in the development of efficient methodologies for the synthesis of quinoline derivatives. The main objective of the present investigation is to provide the synthesis of some novel substituted 3-(2-chloroquinolin-3-yl)acrylic acid. The Knoevenagel condensation is one of the most effective synthetic method for the synthesis of several important key products that include unsaturated acids and unsaturated ester intermediates employed in the synthesis of several therapeutic drugs (e.g. Niphendipine

A Green Protocol for Synthesis of Some Novel 3-(2-Chloroquinolin-3-yl)acrylic Acid via Knoevenagal Reaction