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Three simple, rapid and sensitive spectrophotometric methods were developed for the determination of Erlotinib hydrochloride in pharmaceutical formulations. Beer's law was obeyed over a concentration range 0.5-30 μg/mL in HCl and acetate buffer and 1-30 μg/mL in phosphate buffer. The linear regression equations were found to be y = 0.0717x + 0.0083, y = 0.0676x + 0.0102 and y = 0.0638x + 0.0096 in HCl, acetate buffer and phosphate buffer respectively and the three methods were validated as per ICH guidelines.

Analytical Techniques for the Determination of Erlotinib HCl in Pharmaceutical Dosage Forms by Spectrophotometry