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L-Tyrosine has been utilized as an efficient and eco-friendly catalyst for the Knoevenagel condensation of arylaldehydes 1(a-k) with barbituric acid and 2-thiobarbituric acid containing cyclic active methylene groups in aqueous medium at room temperature to produce 5-arylidene-pyrimidine- 2,4,6-triones and 5-arylidene-2-thioxo-dihydro-pyrimidine-4,6-diones 3(a-p).

chemical science transactions

Facile and Green Syntheses of 5-Arylidene-pyrimidine-2,4,6-triones and 5-Arylidene-2-thioxo-dihydro-pyrimidine-4,6-diones Using L-Tyrosine as an Efficient and Eco-Friendly Catalyst in Aqueous Medium